Progeria, rapamycin and normal aging: Recent breakthrough

  • Blagosklonny M
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Abstract

A recent discovery that rapamycin suppresses a pro-senescent phenotype in progeric cells not only suggests a non-toxic therapy for progeria but also implies its similarity with normal aging. For one, rapamycin is also known to suppress aging of regular human cells. Here I discuss four potential scenarios, comparing progeria with both normal and accelerated aging. This reveals further indications of rapamycin both for accelerated aging in obese and for progeria.

Author-supplied keywords

  • Aging
  • Autophagy
  • Obesity
  • Progeria
  • Rapamycin
  • Senescence

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Authors

  • Mikhail V. Blagosklonny

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