Programming effects of short prenatal exposure to dexamethasone in sheep

  • Dodic M
  • Abouantoun T
  • O'Connor A
 et al. 
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Abstract

Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure in male and female offspring and whether hypertension in males was modulated by testosterone status, and (2) altered gene expression for angiotensinogen and angiotensin type 1 (AT1) receptors in the brain in late gestation and in the adult. Basal mean arterial pressure (MAP) at 2 years of age was significantly higher in wethers exposed to prenatal dexamethasone (group D; 106{+/-}5 mm Hg, n=9) compared with the control group (group S; 91{+/-}3 mm Hg, n=8; P

Author-supplied keywords

  • Brain
  • Glucocorticoids
  • Hypertension, experimental
  • Sheep

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Authors

  • Miodrag Dodic

  • Tamara Abouantoun

  • Anne O'Connor

  • E. Marelyn Wintour

  • Karen M. Moritz

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