Promoter architecture and the evolvability of gene expression

  • Tirosh I
  • Barkai N
  • Verstrepen K
 et al. 
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Abstract

Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome-covered promoter and unstable tracts of tandem repeats. Here, we discuss how these promoter properties may confer an inherent capacity for flexibility of expression.

Author-supplied keywords

  • Biomedicine general
  • Life Sciences
  • general

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Authors

  • Itay Tirosh

  • Naama Barkai

  • Kevin J Verstrepen

  • MC King

  • AC Wilson

  • EH Davidson

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