Prophylaxis with teicoplanin and cefuroxime reduces the rate of prosthetic joint infection after primary arthroplasty

  • Tornero E
  • Garcí-Ramiro S
  • Martínez-Pastor J
 et al. 
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Abstract

The aim of this study was to compare the prosthetic joint infection (PJI) rate after total joint arthroplasty in two consecutive periods with different antibiotic prophylaxis: cefuroxime versus cefuroxime plus teicoplanin. We retrospectively reviewed 1897 patients who underwent THA or TKA between March 2010 and February 2013. From March 2010 to August 2011, patients received 1.5 g of cefuroxime during induction of anaesthesia and another 1.5 g 2 hours later (C-group). From September 2011, 800 mg of teicoplanin was added to cefuroxime (CT-group). Throughout the studied period there were no variations in pre- or post-operative protocols. Univariate and multivariate analysis were performed to evaluate independent predictors of PJI. There were 995 (55.7%) patients in C-group and 791 (44.3%) in CT-group. Patients in CT-group had a significantly lower PJI rate than C-group (1.26% vs 3.51%, P=0.002). There were no infections due to S. aureus in CT-group (0% vs 1.6%, P

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Authors

  • Misericordia BasoraHospital Clinic de Barcelona

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  • Eduard Tornero

  • Sebastian Garcí-Ramiro

  • Juan C. Martínez-Pastor

  • Guillem Bori

  • Jordi Bosch

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