Propranolol treatment of congestive heart failure in infants with congenital heart disease: The CHF-PRO-INFANT Trial. Congestive heart failure in infants treated with propanol

  • Buchhorn R
  • Hulpke-Wette M
  • Hilgers R
 et al. 
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Abstract

AIM: Infants with congenital heart disease and left-to-right shunts may develop significant clinical symptoms of congestive heart failure in spite of therapy with digoxin and diuretics. We investigated the effects of beta-blockade in infants with severe heart failure. METHODS AND RESULTS: We performed a prospective, randomized, open monocenter trial in infants treated with digoxin and diuretics (n=10) in comparison to 10 infants receiving additional beta-blocker therapy. After 17 days on average beta-blocker treated infants (propranolol:1,6 mg/kg/day) improved significantly with respect to Ross heart failure score (3.3+/-2.3 vs. 8.3+/-1.9, P=0.002), lower renin levels (338+/-236 vs. 704+/-490 microU/l, P=0.008) and lower mean heart rates in Holter ECG (118+/-10 vs. 142+/-11 beats/min, P

Author-supplied keywords

  • Adrenergic beta-Antagonists/*therapeutic use
  • Cardiotonic Agents/therapeutic use
  • Comparative Study
  • Digoxin/therapeutic use
  • Diuretics/therapeutic use
  • Heart Defects, Congenital/*complications
  • Heart Failure, Congestive/*drug therapy/etiology
  • Heart Rate/drug effects
  • Heart Septal Defects/*complications
  • Hemodynamic Processes/drug effects
  • Hormones/blood
  • Humans
  • Infant
  • Infant, Newborn
  • Propranolol/*therapeutic use
  • Prospective Studies
  • Severity of Illness Index
  • Statistics, Nonparametric

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Authors

  • R Buchhorn

  • M Hulpke-Wette

  • R Hilgers

  • D Bartmus

  • A Wessel

  • J Bursch

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