Prospective derivation and validation of a clinical prediction rule for recurrent Clostridium difficile infection.

  • Hu M
  • Katchar K
  • Kyne L
 et al. 
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Prevention of recurrent Clostridium difficile infection (CDI) is a substantial therapeutic challenge. A previous prospective study of 63 patients with CDI identified risk factors associated with recurrence. This study aimed to develop a prediction rule for recurrent CDI using the above derivation cohort and prospectively evaluate the performance of this rule in an independent validation cohort.

Author-supplied keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents
  • Anti-Bacterial Agents: therapeutic use
  • Bacterial Toxins
  • Bacterial Toxins: immunology
  • Clostridium difficile
  • Clostridium difficile: pathogenicity
  • Enterocolitis, Pseudomembranous
  • Enterocolitis, Pseudomembranous: blood
  • Enterocolitis, Pseudomembranous: epidemiology
  • Enterocolitis, Pseudomembranous: prevention & cont
  • Enterotoxins
  • Enterotoxins: immunology
  • Female
  • Humans
  • Immunoglobulin G
  • Immunoglobulin G: blood
  • Logistic Models
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • ROC Curve
  • Recurrence
  • Recurrence: prevention & control
  • Risk Factors
  • Sensitivity and Specificity

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  • Mary Y Hu

  • Kianoosh Katchar

  • Lorraine Kyne

  • Seema Maroo

  • Sanjeev Tummala

  • Valley Dreisbach

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