A prospective study of diet and the risk of symptomatic diverticular disease in men

  • Aldoori W
  • Giovannucci E
  • Rimm E
 et al. 
  • 2


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


To examine the association between dietary fiber, sources of fiber, other nutrients, and the diagnosis of symptomatic diverticular disease, we analyzed data from a prospective cohort of 47,888 US men. During 4 y of follow-up we documented 385 new cases of symptomatic diverticular disease. Total dietary fiber intake was inversely associated with the risk of diverticular disease after adjustment for age, energy-adjusted total fat intake, and physical activity [relative risk (RR) 0.58; 95% CI 0.41, 0.83; P for trend = 0.01 for men in the highest as compared with the lowest quintile of dietary fiber]. This inverse association was primarily due to fruit and vegetable fiber. For men on a high-total-fat, low-fiber diet, the RR was 2.35 (95% CI 1.38, 3.98) compared with those on a low-total-fat, high-fiber diet, and for men on a high-red-meat, low-fiber diet the RR was 3.32 (95% CI 1.46, 7.53) compared with those on a low-red-meat, high-fiber diet. These prospective data support the hypothesis that a diet low in total dietary fiber increases the incidence of symptomatic diverticular disease. They also provide evidence that the combination of high intake of total fat or red meat and a diet low in total dietary fiber particularly augments the risk.

Author-supplied keywords

  • Adult
  • Aged
  • Dietary Fats/*administration & dosage/adverse effe
  • Dietary Fiber/*administration & dosage
  • Diverticulum/*etiology/prevention & control
  • Humans
  • Intestinal Diseases/*etiology/prevention & control
  • Male
  • Middle Aged
  • Prospective Studies
  • Questionnaires
  • Risk Factors
  • United States

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • W H Aldoori

  • E L Giovannucci

  • E B Rimm

  • A L Wing

  • D V Trichopoulos

  • W C Willett

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free