A prospective study of diet and the risk of symptomatic diverticular disease in men.

  • Aldoori W
  • Giovannucci E
  • Rimm E
 et al. 
  • 40

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Abstract

To examine the association between dietary fiber, sources of fiber, other nutrients, and the diagnosis of symptomatic diverticular disease, we analyzed data from a prospective cohort of 47,888 US men. During 4 y of follow-up we documented 385 new cases of symptomatic diverticular disease. Total dietary fiber intake was inversely associated with the risk of diverticular disease after adjustment for age, energy-adjusted total fat intake, and physical activity [relative risk (RR) 0.58; 95% CI 0.41, 0.83; P for trend = 0.01 for men in the highest as compared with the lowest quintile of dietary fiber]. This inverse association was primarily due to fruit and vegetable fiber. For men on a high-total-fat, low-fiber diet, the RR was 2.35 (95% CI 1.38, 3.98) compared with those on a low-total-fat, high-fiber diet, and for men on a high-red-meat, low-fiber diet the RR was 3.32 (95% CI 1.46, 7.53) compared with those on a low-red-meat, high-fiber diet. These prospective data support the hypothesis that a diet low in total dietary fiber increases the incidence of symptomatic diverticular disease. They also provide evidence that the combination of high intake of total fat or red meat and a diet low in total dietary fiber particularly augments the risk.

Author-supplied keywords

  • 20th century problem
  • 5 6 in contrast
  • a disease of
  • cohort
  • colon
  • diverticula
  • diverticular disease
  • exercise
  • or
  • physical activity
  • to its rarity
  • western civilisation

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Authors

  • W H Aldoori

  • E L Giovannucci

  • E B Rimm

  • a L Wing

  • D V Trichopoulos

  • W C Willett

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