Prospective study of hippocampal volume and function in human subjects treated with corticosteroids

  • Hájek T
  • Kopeček M
  • Preiss M
 et al. 
  • 2

    Readers

    Mendeley users who have this article in their library.
  • 17

    Citations

    Citations of this article.

Abstract

Purpose. - Decreased hippocampal volume reported in neuropsychiatric and endocrine disorders is considered a result of putative neuronal damage mediated by corticosteroids. This is the first prospective study of hippocampal volume and function in patients treated with corticosteroids. Methods. - 14 subjects treated systemically with prednisone or betamethasone for dermatological or rheumatic disorders underwent prospective neurocognitive testing (Auditory Verbal Learning Test - AVLT, Trail Making Test - TMT, Digit Span - DS) and nine of them also repeated magnetic resonance volumetry. Results. - The mean duration of treatment between the first and the second assessment was 73 ± 38 days with mean daily dose of 37 ± 17 mg prednisone and 193 ± 29 days, with mean daily dose of 24 ± 15 mg prednisone between the first and the third assessment. There was a trend towards decreases in total AVLT scores and an improvement in the TMT and DS, but no significant changes in the volumes of the right or the left hippocampi between the assessments. Prednisone dose did not correlate with the hippocampal volume change. Conclusion. - We observed a trend for decline in verbal memory despite improvement in psychomotor speed, attention/working memory and no macroscopic hippocampal volume changes during 36-238 days of treatment with therapeutic doses of corticosteroids. © 2005 Elsevier SAS. All rights reserved.

Author-supplied keywords

  • Corticosteroids
  • Hippocampus
  • Magnetic resonance imaging
  • Memory

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Martin AldaDalhousie University

    Follow
  • Tomáş Hájek

  • Miloslav Kopeček

  • Marek Preiss

  • Cyril Höschl

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free