Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.

  • Fribley A
  • Evenchik B
  • Zeng Q
 et al. 
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Abstract

Cisplatin is one of the most common DNA-damaging agents used for treating patients with solid tumors such as squamous cell carcinoma (SCC). Unfortunately, significant levels of resistance in SCC cells emerge rapidly following cisplatin treatment. Here we report that the proteasome inhibitor PS-341, the representative of a new class of chemotherapeutic drugs, was capable of inducing apoptosis in cisplatin-resistant SCC cells via the endoplasmic reticulum stress.

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Authors

  • Andrew M. Fribley

  • Benjamin Evenchik

  • Qinghua Zeng

  • Bae Keun Park

  • Jean Y. Guan

  • Honglai Zhang

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