Protective efficacy of vaccination by recombinant vaccinia virus against Neospora caninum infection

  • Nishikawa Y
  • Inoue N
  • Xuan X
 et al. 
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The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The present study indicated that a high level of IgG1 Ab production to parasite is important for clearance of parasite at the early stage of infection and that T cell response has a crucial role for protection against the intracellular infection at the late stage of infection. The recombinant vaccinia viruses might be applicable as vaccine against N. caninum infection in a natural host.

Author-supplied keywords

  • Animals Antibodies, Monoclonal Antibodies, Protozo

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  • Y Nishikawa

  • N Inoue

  • X Xuan

  • H Nagasawa

  • I Igarashi

  • K Fujisaki

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