The recombinant vaccinia viruses expressing the surface protein of Neospora caninum tachyzoite, NcSAG1 or NcSRS2, were constructed. The vaccination with these recombinant viruses could protect effectively the parasite invasion in a mouse model system. The vaccine efficacy of NcSRS2 was higher than that of NcSAG1. The present study indicated that a high level of IgG1 Ab production to parasite is important for clearance of parasite at the early stage of infection and that T cell response has a crucial role for protection against the intracellular infection at the late stage of infection. The recombinant vaccinia viruses might be applicable as vaccine against N. caninum infection in a natural host. © 2001 Elsevier Science Ltd.
CITATION STYLE
Nishikawa, Y., Inoue, N., Xuan, X., Nagasawa, H., Igarashi, I., Fujisaki, K., … Mikami, T. (2001). Protective efficacy of vaccination by recombinant vaccinia virus against Neospora caninum infection. Vaccine, 19(11–12), 1381–1390. https://doi.org/10.1016/S0264-410X(00)00389-3
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