Protein Design: Past, Present, and Future

  • Regan L
  • Caballero D
  • Hinrichsen M
 et al. 
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Building on the pioneering work of Ho and DeGrado (J Am Chem Soc 1987, 109, 6751-6758) in the late 1980s, protein design approaches have revealed many fundamental features of protein structure and stability. We are now in the era that the early work presaged - the design of new proteins with practical applications and uses. Here we briefly survey some past milestones in protein design, in addition to highlighting recent progress and future aspirations. (C) 2015 Wiley Periodicals, Inc.

Author-supplied keywords

  • 4-helix bundle protein
  • Biochemistry & Molecular Biology
  • Biophysics
  • amino-acids
  • coiled-coil
  • computation
  • computational
  • de-novo design
  • dihedral angle distributions
  • enzyme design
  • force-fields
  • green-fluorescent protein
  • hard-sphere models
  • nanotechnology
  • protein design
  • review
  • spytag-spycatcher chemistry

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  • L Regan

  • D Caballero

  • M R Hinrichsen

  • A Virrueta

  • D M Williams

  • C S O'Hern

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