Protein engineering 20 years on

  • Brannigan J
  • Wilkinson A
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Abstract

It is 20 years since site-directed mutagenesis was first used to modify the active site of an enzyme of known structure and mechanism. Since then, this method has contributed far-reaching insights into catalysis, specificity, stability and folding of proteins. Engineered proteins are now being used in industry and for the improved treatment of human disease.

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  • stability

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Authors

  • James A Brannigan

  • Anthony J Wilkinson

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