Protein translocon at the Arabidopsis outer chloroplast membrane

  • Hiltbrunner A
  • Bauer J
  • Alvarez-Huerta M
 et al. 
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Chloroplasts are organelles essential for the photoautotrophic growth of plants. Their biogenesis from undif- ferentiated proplastids is triggered by light and requires the import of hundreds of different precursor proteins from the cytoplasm. Cleavable N-terminal transit sequences target the precursors to the chloroplast where translocon complexes at the outer (Toc complex) and inner (Tic complex) envelope membranes enable their import. In pea, the Toc complex is trimeric consisting of two surface-exposed GTP-binding proteins (Toc159 and Toc34) involved in precursor recogni- tion and Toc75 forming an aequeous protein-conducting channel. Completion of the Arabidopsis genome has revealed an unexpected complexity of predicted components of the Toc complex in this plant model organism: four genes en- code homologs of Toc159, two encode homologs of Toc34, but only one encodes a likely functional homolog of Toc75. The availability of the genomic sequence data and powerful molecular genetic techniques in Arabidopsis set the stage to unravel the mechanisms of chloroplast protein import in unprecedented depth.

Author-supplied keywords

  • arabidopsis
  • chloroplast
  • genetics
  • hiltbrunner
  • les chloroplastes sont des
  • organites essentiels pour la
  • protein import
  • résumé

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  • A. Hiltbrunner

  • J. Bauer

  • M. Alvarez-Huerta

  • F. Kessler

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