Proton magnetic resonance spectroscopy of human cervical spondylosis at 3T

  • N. S
  • B.M. E
  • R. N
 et al. 
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Abstract

Study design:A single-center magnetic resonance imaging and spectroscopic study involving 21 patients with advanced cervical spondylosis and 11 healthy controls.Objective:We assessed the utility of magnetic resonance spectroscopy (MRS) to quantify biochemical changes within the spinal cord and serve as a potential biomarker in patients with cervical spondylosis with or without T2 hyperintensity within the cord.Setting:Los Angeles, California, USA.Methods:Twenty-one patients with cervical spondylosis and eleven healthy controls were evaluated. Single-voxel MRS was performed in the cervical cord. Morphometry of the spinal canal space was measured. N-Acetyl aspartylglutamic acid (NAA), choline (Cho), myo-inositol (Myo-I), glutamine-glutamate complex (Glx) and lactate metabolite concentration ratios with respect to total creatine (Cr) were quantified using an LC model algorithm and compared between healthy controls and spondylosis patients. Correlation of MRS metabolites with modified Japanese Orthopaedic Association (mJOA) score was also performed.Results:The spinal canal space was significantly different between patients and controls (analysis of variance (ANOVA), P

Author-supplied keywords

  • *cervical spondylosis
  • *cervical spondylosis/di [Diagnosis]
  • *human
  • *nuclear magnetic resonance imaging
  • *nuclear magnetic resonance spectroscopy
  • *proton nuclear magnetic resonance
  • *spinal cord
  • *spinal cord disease
  • *stenosis
  • Japanese Orthopaedic Association score
  • United States
  • adult
  • algorithm
  • analysis of variance
  • article
  • biological marker
  • cervical spinal cord
  • choline
  • choline/ec [Endogenous Compound]
  • clinical article
  • comparative study
  • controlled study
  • correlation analysis
  • creatine
  • creatine/ec [Endogenous Compound]
  • diagnostic value
  • female
  • glutamic acid
  • glutamine
  • human
  • inositol
  • inositol/ec [Endogenous Compound]
  • lactic acid/ec [Endogenous Compound]
  • male
  • metabolite
  • model
  • morphometrics
  • n acetylaspartylglutamic acid
  • n acetylaspartylglutamic acid/ec [Endogenous Compo
  • patient
  • priority journal
  • spondylosis
  • study design
  • vertebral canal
  • voxel based morphometry

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Authors

  • Salamon N.

  • Ellingson B.M.

  • Nagarajan R.

  • Gebara N.

  • Thomas A.

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