Publication of trials funded by the National Heart, Lung, and Blood Institute

  • Gordon D
  • Taddei-Peters W
  • Mascette A
 et al. 
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BACKGROUND: Rapid publication of clinical trials is essential in order for the findings to yield maximal benefits for public health and scientific progress. Factors affecting the speed of publication of the main results of government-funded trials have not been well characterized. METHODS: We analyzed 244 extramural randomized clinical trials of cardiovascular interventions that were supported by the National Heart, Lung, and Blood Institute (NHLBI). We selected trials for which data collection had been completed between January 1, 2000, and December 31, 2011. Our primary outcome measure was the time between completion of the trial and publication of the main results in a peer-reviewed journal. RESULTS: As of March 31, 2012, the main results of 156 trials (64%) had been published (Kaplan-Meier median time to publication, 25 months, with 57% published within 30 months). Trials that focused on clinical events were published more rapidly than those that focused on surrogate measures (median, 9 months vs. 31 months; P

Author-supplied keywords

  • *National Heart, Lung, and Blood Institute (U.S.)
  • *Research Support as Topic
  • Cardiovascular Diseases/therapy
  • Financing, Government
  • Humans
  • Kaplan-Meier Estimate
  • Periodicals as Topic/*statistics & numerical data
  • Publishing/*statistics & numerical data
  • Randomized Controlled Trials as Topic/economics/*s
  • Time Factors
  • United States

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  • D Gordon

  • W Taddei-Peters

  • a Mascette

  • M Antman

  • P G Kaufmann

  • M S Lauer

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