A putative nuclear function for mammalian Staufen

  • Kiebler M
  • Jansen R
  • Dahm R
 et al. 
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Abstract

In addition to its role in rRNA processing and ribosome assembly, the nucleolus plays a part in the assembly of non-ribosomal ribonucleoprotein particles (RNPs) that are destined for cytoplasmic RNA delivery. Recent evidence indicates that mammalian Staufen2, a brain-specific RNA-binding protein involved in RNA localization, can - at least transiently - enter the nucleolus. Therefore, the assembly of Staufen2 into transport-competent RNPs might occur in the nucleus before their export into the cytoplasm. This could provide new insights into the mechanisms of subcellular RNA localization. © 2005 Elsevier Ltd. All rights reserved.

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Authors

  • Michael A. Kiebler

  • Ralf Peter Jansen

  • Ralf Dahm

  • Paolo Macchi

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