In addition to its role in rRNA processing and ribosome assembly, the nucleolus plays a part in the assembly of non-ribosomal ribonucleoprotein particles (RNPs) that are destined for cytoplasmic RNA delivery. Recent evidence indicates that mammalian Staufen2, a brain-specific RNA-binding protein involved in RNA localization, can - at least transiently - enter the nucleolus. Therefore, the assembly of Staufen2 into transport-competent RNPs might occur in the nucleus before their export into the cytoplasm. This could provide new insights into the mechanisms of subcellular RNA localization. © 2005 Elsevier Ltd. All rights reserved.
CITATION STYLE
Kiebler, M. A., Jansen, R. P., Dahm, R., & Macchi, P. (2005). A putative nuclear function for mammalian Staufen. Trends in Biochemical Sciences. Elsevier Ltd. https://doi.org/10.1016/j.tibs.2005.03.005
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