The putative role of leukotrienes in experimental atherogenesis

  • Jawień J
  • 5


    Mendeley users who have this article in their library.
  • 15


    Citations of this article.


Since inflammation plays an important role in atherogenesis, during recent years it has become apparent that the 5-lipoxygenase (5-LO) pathway may take a significant part in the pathogenesis of atherosclerosis. These data raised the possibility that antileukotriene drugs may be an effective treatment regimen in atherosclerosis. This review describes the research performed on the apolipoprotein E/low-density lipoprotein receptor-double knockout mice as a model of atherosclerosis. The study has shown that 5-LO activating protein inhibitors and leukotriene receptor blockers decrease atherosclerosis in atherosclerotic mice. The article also discusses the importance of these findings for the future use in the clinic.

Author-supplied keywords

  • 5-lipoxygenase activating protein (FLAP)
  • Atherosclerosis
  • Leukotriene

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 19341185
  • PUI: 354234226
  • SGR: 61349157875
  • SCOPUS: 2-s2.0-61349157875
  • ISSN: 00323772


  • Jacek Jawień

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free