Pyridoxine-induced photosensitivity and hypophosphatasia

9Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.
Get full text

Abstract

We describe a case of photosensitivity due to pyridoxine hydrochloride (vitamin B6) in a heterozygote of hypophosphatasia. Photopatch tests using pyridoxine hydrochloride and pyridoxal 5′-phosphate, compounds referred to as vitamin B6, with ultraviolet light A irradiation were positive. Laboratory examination showed low serum alkaline phosphatase. Tissue-nonspecific alkaline phosphatase exon amplification from DNA of the patient's lymphocytes detected deletion 1154-1156 hypophosphatasia mutation, indicating that this patient was diagnosed to be a heterozygote of hypophosphatasia. The seric pyridoxal 5′-phosphate level of this patient with hypophosphatasia was higher than in normals. Furthermore, after oral administration of vitamin B6 this level increased greatly and long-lastingly, and this might be related to the low level of alkaline phosphatase in this patient. Photosensitivity in this patient may have been caused by abnormal metabolism of vitamin B6 under the hypophosphatic condition. Copyright © 2000 S. Karger AG, Basel.

Cite

CITATION STYLE

APA

Kawada, A., Kashima, A., Shiraishi, H., Gomi, H., Matsuo, I., Yasuda, K., … Orimo, H. (2000). Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology, 201(4), 356–360. https://doi.org/10.1159/000051555

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free