Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase i study for the treatment of parkinson disease

  • Valles F
  • Fiandaca M
  • Eberling J
 et al. 
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Abstract

Putaminal convection-enhanced delivery (CED) of an adeno-associated virus serotype 2 (AAV2) vector, containing the human aromatic L-amino acid decarboxylase (hAADC) gene for the treatment of Parkinson disease (PD), has completed a phase I clinical trial.

Author-supplied keywords

  • AAV2-hAADC
  • Convection-enhanced delivery
  • Gene therapy
  • Magnetic resonance imaging
  • Parkinson disease
  • Positron emission tomography

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