QuantiFERON-TB Gold in the identification of latent tuberculosis infection in rheumatoid arthritis: a pilot study.

  • Shovman O
  • Anouk M
  • Vinnitsky N
 et al. 
  • 21

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Abstract

OBJECTIVE: To compare the performance of QuantiFERON-TB Gold (QFT-G) with that of the tuberculin skin test (TST) in detecting latent tuberculosis (LTBI) among patients with rheumatoid arthritis (RA)., PATIENTS AND METHODS: A total of 35 RA patients and 15 healthy controls underwent TST, QFT-G assays and chest X-ray and filled out a questionnaire on predisposing conditions for TB disease. Serum interferon gamma (IFN-gamma) levels were tested by an enzyme-linked immunosorbent assay., RESULTS: Forty-five per cent of RA patients had a TST > 5 mm vs. 26% in healthy controls. In the RA patients, QFT-G was positive in 11.4%, negative in 60% and indeterminate in 28.6%. The overall agreement between TST and QFT-G was significantly lower in the RA population than in controls (56% vs. 84%). No correlation was found between the use of prednisone, methotrexate and QFT-G results or agreement between TST and QFT-G. A low IFN-gamma level (

Author-supplied keywords

  • *Arthritis, Rheumatoid/co [Complications]
  • *Enzyme-Linked Immunosorbent Assay
  • *Interferon-gamma/bl [Blood]
  • *Latent Tuberculosis/di [Diagnosis]
  • *Mycobacterium/im [Immunology]
  • *Reagent Kits, Diagnostic
  • *Tuberculin Test
  • Antirheumatic Agents/tu [Therapeutic Use]
  • Arthritis, Rheumatoid/dt [Drug Therapy]
  • Biological Markers/bl [Blood]
  • Case-Control Studies
  • Female
  • Humans
  • Latent Tuberculosis/mi [Microbiology]
  • Latent Tuberculosis/ra [Radiography]
  • Male
  • Methotrexate/tu [Therapeutic Use]
  • Middle Aged
  • Pilot Projects
  • Predictive Value of Tests
  • Prednisone/tu [Therapeutic Use]
  • Questionnaires

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Authors

  • O Shovman

  • M Anouk

  • N Vinnitsky

  • U Arad

  • D Paran

  • I Litinsky

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