Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome

  • Camp R
  • Dolled-Filhart M
  • King B
 et al. 
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Abstract

Using a tissue microarray cohort of 300 breast cancers and 84 samples of normal breast epithelium, we analyzed HER2/neu expression and com-pared traditional clinical (manual) scoring with a recently developed system for the quantitative measurement of immunohistochemical stains (AQUA). As expected, both methods identified a population (10 –15%) of high-HER2-expressing tumors with poor 30-year disease-related survival. Using AQUA analysis, we found that normal epithelium expresses a low but detectable level of HER2 and that 17.5% of tumors exhibit similar low-level HER2 expression. This low group was not definable by manual scoring. Surprisingly, HER2-normal tumors were as aggressive as HER2-overexpressing tumors. Our studies suggest that in situ quantitative meas-urement of HER2 stratifies breast tumors into three expression levels: normal, intermediate, and high, where both normal and high levels are associated with a worse outcome.

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  • PUI: 36373626
  • PMID: 12670887
  • SCOPUS: 2-s2.0-0037382283
  • ISSN: 00085472
  • SGR: 0037382283

Authors

  • Robert L. Camp

  • Marisa Dolled-Filhart

  • Bonnie L. King

  • David L. Rimm

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