Quantitative analysis of Hedgehog gradient formation using an inducible expression system

  • Su V
  • Jones K
  • Brodsky M
 et al. 
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Abstract

The Hedgehog (Hh) family of secreted growth factors are morphogens that act in development to direct growth and patterning. Mutations in human Hh and other Hh pathway components have been linked to human diseases. Analysis of Hh distribution during development indicates that cholesterol modification and receptor mediated endocytosis affect the range of Hh signaling and the cellular localization of Hh.

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Authors

  • Vivian F. Su

  • Kelly A. Jones

  • Michael Brodsky

  • Inge The

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