Quantitative assessment of emphysema, air trapping, and airway thickening on computed tomography

  • Lee Y
  • Oh Y
  • Lee J
 et al. 
  • 58


    Mendeley users who have this article in their library.
  • 136


    Citations of this article.


The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of this study is to evaluate the correlation between the parameters measured on volumetric CT, including the extent of emphysema, air trapping, and airway thickening, and clinical parameters. CT scans were performed in 34 patients with COPD at full inspiration and expiration. We used in-house software to measure CT parameters, including volume fraction of emphysema (V(950)), mean lung density (MLD), CT air trapping index (CT ATI), segmental bronchial wall area (WA), lumen area (LA), and wall area percent (WA%). We found that the CT parameters were correlated with the pulmonary function test (PFT) results, body mass index (BMI), the modified Medical Research Council Dyspnea scale (MMRC scale), the six-minute-walk distance (6MWD), and the BODE index. V(950 insp) correlated to the BMI, FEV(1), 6MWD, and the BODE index. The CT ATI correlated with the physiologic ATI (VC-FVC) (R=0.345, p=0.045) and the MMRC scale (R=0.532, p=0.001). There was a positive correlation between the WA% and the BMI (R=0.563, p

Author-supplied keywords

  • Air trapping
  • BMI
  • BODE index
  • COPD
  • Diagnostic imaging
  • Lung attenuation
  • MDCT imaging techniques in COPD
  • Respiratory function test
  • Walking test
  • Wall area

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Young Kyung Lee

  • Yeon Mok Oh

  • Ji Hyun Lee

  • Eun Kyung Kim

  • Jin Hwa Lee

  • Namkug Kim

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free