Quantitative assessment of fibrosis in liver biopsies from patients with chronic hepatitis B

  • Hui A
  • Liew C
  • Go-Minnie Y
 et al. 
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BACKGROUND/AIM: Accurate histological assessment of liver fibrosis is essential in the management of chronic hepatitis B (CHB). Although semi-quantitative scoring systems describe well the pathological patterns of hepatic structure, they produce fibrosis evaluation that is not very precise. Image analysis or morphometry has the theoretical advantage of providing truly quantitative data. PATIENTS AND METHODS: The present study aimed at validating a new image analysis system, Bioquant Nova Prime, in estimating collagen content in liver biopsy samples from patients with CHB. The biopsies were stained with picrosirius red and the areas of collagen were measured. The results were correlated with laboratory parameters and Ishak modified histological scores. Discriminative reliability of morphometry was determined using receiver operating characteristics (ROC) analysis. RESULTS: There was excellent interobserver agreement (r=0.84-0.94, P

Author-supplied keywords

  • agreement
  • analysis
  • biopsy
  • chronic hepatitis
  • cirrhosis
  • evaluation
  • fibrosis
  • hepatitis
  • hepatitis B
  • liver
  • liver biopsy
  • liver fibrosis
  • management
  • methods
  • patients
  • quantification
  • response
  • studies
  • therapy
  • treatment
  • variability

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  • Alex Yui Hui

  • Choong Tsek Liew

  • Yin Yin Go-Minnie

  • Angel Mei Chim

  • Lik Yuen Chan-Henry

  • Wai Yee Leung-Nancy

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