Quantitative CARS spectroscopy using the maximum entropy method: The main lipid phase transition

  • Rinia H
  • Bonn M
  • Müller M
 et al. 
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The maximum entropy method for phase retrieval of multiplex coherent
anti-Stokes Raman scattering (CARS) spectra is described in detail
and applied to the time-resolved measurement of the main lipid phase
transition of small, unilamellar 1,2-dimyristoyl-sn-glycero-3-phosphocholine
(DMPC) vesicles subject to a 3 min temperature sweep. Since the--thus
derived--imaginary part of the third-order CARS susceptibility can
be directly related to the linear vibrational spectrum, the multiplex
CARS spectral data can be analyzed quantitatively and without prior
knowledge of the sample. It is shown that the maximum entropy model
provides an exact description of the original data, including the
noise, if all available autocorrelation functions are used. Our findings
confirm the acyl-chain order-disorder phase-transition behavior of
small, unilamellar lipid vesicles.

Author-supplied keywords

  • Biophysics
  • CARS (coherent anti-Stokes Raman scattering)
  • Lipids
  • Membranes
  • Raman spectroscopy

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