The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure

  • Hodgson J
  • Darnton A
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Abstract

Mortality reports on asbestos exposed cohorts which gave information on exposure levels from which (as a minimum) a cohort average cumulative exposure could be estimated were reviewed. At exposure levels seen in occupational cohorts it is concluded that the exposure specific risk of mesothelioma from the three principal commercial asbestos types is broadly in the ratio 1:100:500 for chrysotile, amosite and crocidolite respectively. For lung cancer the conclusions are less clear cut. Cohorts exposed only to crocidolite or amosite record similar exposure specific risk levels (around 5% excess lung cancer per f/ml.yr); but chrysotile exposed cohorts show a less consistent picture, with a clear discrepancy between the mortality experience of a cohort of xhrysotile textile workers in Carolina and the Quebec miners cohort. Taking account of the excess risk recorded by cohorts with mixed fibre exposures (generally

Author-supplied keywords

  • Amphibole hypothesis
  • Asbestos
  • Exposure-response
  • Lung cancer
  • Mesothelioma
  • Quantified risk assessment

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Authors

  • John T. Hodgson

  • Andrew Darnton

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