Quick and effective hyperpolarization of the membrane potential in intact smooth muscle cells of blood vessels by synchronization modulation electric field

  • Zhang L
  • Fang Z
  • Chen W
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Blood vessel dilation starts from activation of the Na/K pumps and
inward rectifier K channels in the vessel smooth muscle cells, which
hyperpolarizes the cell membrane potential and closes the Ca channels.
As a result, the intracellular Ca concentration reduces, and the smooth
muscle cells relax and the blood vessel dilates. Activation of the Na/K
pumps and the membrane potential hyperpolarization plays a critical role
in blood vessel functions. Previously, we developed a new technique,
synchronization modulation, to control the pump functions by
electrically entraining the pump molecules. We have applied the
synchronization modulation electric field noninvasively to various
intact cells and demonstrated the field-induced membrane potential
hyperpolarization. We further applied the electric field to blood
vessels and investigated the field induced functional changes of the
vessels. In this paper, we report the results in a study of the membrane
potential change in the smooth muscle cells of mesenteric blood vessels
in response to the oscillating electric field. We found that the
synchronization modulation electric field can effectively hyperpolarize
the muscle membrane potential quickly in seconds under physiological

Author-supplied keywords

  • Hyperpolarization
  • Membrane potential
  • Na/K pump
  • Synchronization modulation

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  • Liping Zhang

  • Zhihui Fang

  • Wei Chen

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