Randomised clinical trial: The efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

  • Krarup A
  • Ny L
  • Åstrand M
 et al. 
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Abstract

Many patients with gastro-oesophageal reflux disease (GERD) are hypersensitive to heat and acid and may respond insufficiently to standard treatment. Antagonists of the heat and acid receptor 'transient receptor potential vanilloid 1'(TRPV1) are a potential drug class for GERD treatment.

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Authors

  • A. L. Krarup

  • L. Ny

  • M. Åstrand

  • A. Bajor

  • F. Hvid-Jensen

  • M. B. Hansen

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