Randomised trial of oral morphine for painful episodes of sickle-cell disease in children.

  • Jacobson S
  • Kopecky E
  • Joshi P
 et al. 
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Oral controlled-release morphine can provide effective analgesia through a non-invasive route and may facilitate outpatient management of severe episodes of sickle-cell pain. We compared the clinical efficacy and safety of oral morphine with continuous intravenous morphine in children with severe episodes of sickle-cell pain, by a double-blind, randomised, parallel-group design.

Author-supplied keywords

  • Administration, Oral
  • Adolescent
  • Anemia, Sickle Cell
  • Anemia, Sickle Cell: complications
  • Anemia, Sickle Cell: drug therapy
  • Child
  • Child, Preschool
  • Delayed-Action Preparations
  • Double-Blind Method
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Morphine
  • Morphine: administration & dosage
  • Pain
  • Pain Measurement
  • Pain Measurement: methods
  • Pain: drug therapy
  • Pain: etiology

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  • S J Jacobson

  • E a Kopecky

  • P Joshi

  • N Babul

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