A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease

  • Narasimhalu K
  • Effendy S
  • CH S
 et al. 
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METHODSThis study was a 24-week, double-blind, randomized, placebo-controlled trial of ischemic stroke patients seen at a tertiary hospital who had cognitive impairment no dementia because of cerebrovascular disease. The intervention was either rivastigmine or placebo up to 9 mg/day. The primary outcome of interest was mean change from baseline in the Ten-Point Clock Drawing and Color Trails 1 and 2.RESULTSFifty patients were randomized into rivastigmine (n = 25) and placebo (n = 25) arms. Patients in the rivastigmine group showed statistically significant improvement (1.70 vs 0.13, P = 0.02) on the animal subtask of the verbal fluency measure compared with placebo. There was also a trend (non-significant) towards improvement in Color Trails II.CONCLUSIONSIn this pilot study, we demonstrated that rivastigmine was well tolerated in patients with CIND because of cerebrovascular disease and may potentially improve executive functioning.OBJECTIVESThe safety and efficacy of early acetylcholinesterase inhibitors therapy in patients with cognitive impairment no dementia (CIND) after a cerebrovascular accident have not been examined. In this study, we investigated the safety and efficacy of rivastigmine in cognition, particularly executive function in patients with CIND because of cerebrovascular disease.

Author-supplied keywords

  • Aged
  • Aged, 80 and over
  • Brain Ischemia*/*complications
  • Cholinesterase Inhibitors*/*administration & dosag
  • Cholinesterase Inhibitors/adverse effects
  • Cognition Disorders*/*drug therapy
  • Cognition Disorders*/*etiology
  • Dementia/drug therapy
  • Dementia/etiology
  • Double-Blind Method
  • Executive Function*/*drug effects
  • Female
  • Humans
  • Male
  • Medical Subject Headings (MeSH)
  • Middle Aged
  • Phenylcarbamates*/*administration & dosage
  • Phenylcarbamates/adverse effects
  • Pilot Projects
  • Rivastigmine
  • Stroke*/*complications
  • Treatment Outcome

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  • K Narasimhalu

  • S Effendy

  • Sim CH

  • Lee JM

  • I Chen

  • Hia SB

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