Rapid fabrication of electrochemical enzyme sensor chip using polydimethylsiloxane microfluidic channel

  • Yamaguchi A
  • Jin P
  • Tsuchiyama H
 et al. 
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Applicability of polydimethylsiloxane (PDMS) for easy and rapid fabrication of enzyme sensor chips, based on electrochemical detection, is examined. The sensor chip consists of PDMS substrate with a microfluidic channel fabricated in it, and a glass substrate with enzyme-modified microelectrodes. The two substrates are clamped together between plastic plates. The sensor chip has shown no leakage around the microelectrodes under continuous solution flow (34μl/min). Amperometric response of the sensor chips developed in this work suggest that various types of enzyme sensors can be designed by using PDMS microfluidic channels. © 2002 Elsevier Science B.V. All rights reserved.

Author-supplied keywords

  • Enzyme sensor
  • Microchannel
  • Microelectrode
  • PDMS

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  • Akira Yamaguchi

  • Peng Jin

  • Hiroshi Tsuchiyama

  • Takao Masuda

  • Kai Sun

  • Shigeki Matsuo

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