Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues

  • Singh A
  • Gailite L
  • Vyas V
 et al. 
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Abstract

Rapid prototyping of titania substrates with micro and nanofeatures is obtained by combining nanosphere lithography with supersonic cluster beam deposition on protein-functionalized glass supports. The proliferation and differentiation of PC12 cells were studied on these substrates. The facile control and modification of the substrate structure at the micro- and nanoscale allowed us to characterize the role of functional and structural features on neuritogenesis and to control this phenomenon by identifying the optimal topography. © 2011 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Cell culture
  • Micropatterning
  • Nanotopography
  • Neural network
  • Titanium oxide

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Authors

  • Ajay V. Singh

  • Lasma Gailite

  • Cristina Lenardi

  • Stefania Forti

  • Michela Matteoli

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