Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses

  • Chiba S
  • Ikushima H
  • Ueki H
 et al. 
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Abstract

The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications.

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Authors

  • Shiho Chiba

  • Hiroaki Ikushima

  • Hiroshi Ueki

  • Hideyuki Yanai

  • Yoshitaka Kimura

  • Sho Hangai

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