Reduced GABAergic Action in the Autistic Brain

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Abstract

An imbalance in inhibitory/excitatory neurotransmission is proposed to affect the autistic brain, but empirical evidence in humans is lacking. Robertson et al. report a link between a robust autistic perceptual symptom and reduced action of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA), in the brains of autistic individuals.

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Robertson, C. E., Ratai, E. M., & Kanwisher, N. (2016). Reduced GABAergic Action in the Autistic Brain. Current Biology, 26(1), 80–85. https://doi.org/10.1016/j.cub.2015.11.019

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