Reduced insulin sensitivity as a marker for acute mountain sickness?.

  • Spliethoff K
  • Meier D
  • Aeberli I
 et al. 
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Abstract

Reduced insulin sensitivity might increase the susceptibility to acute mountain sickness (AMS). The diabetogenic side effects of dexamethasone should therefore be considered for AMS treatment. To examine whether reduced insulin sensitivity is predictive of AMS and how it is affected by dexamethasone at high altitude, we analyzed endocrine and metabolic parameters obtained from healthy mountaineers in Zurich (LA; 490 m), and 2 and 4 days after fast ascent to the Capanna Regina Margherita (HA2, HA4; 4559 m). 14 of 25 participants developed AMS and were treated with dexamethasone starting in the evening of HA2. Before and after ingestion of an 1800 kJ meal, plasma was analyzed for erythropoietin (EPO) and cholecystokinin (CCK). Insulin sensitivity (HOMA-S) and beta cell activity were calculated. HOMA-S (p{

Author-supplied keywords

  • Adult
  • Altitude
  • Altitude Sickness/bl [Blood]
  • Altitude Sickness/dt [Drug Therapy]
  • Anoxia/bl [Blood]
  • Anoxia/co [Complications]
  • Biological
  • Blood Glucose/me [Metabolism]
  • Cholecystokinin/bl [Blood]
  • Dexamethasone/tu [Therapeutic Use]
  • Energy Intake
  • Erythropoietin/bl [Blood]
  • Female
  • Glucocorticoids/tu [Therapeutic Use]
  • Homeostasis
  • Humans
  • Hydrocortisone/bl [Blood]
  • IM
  • Insulin Resistance/ph [Physiology]
  • Insulin-Secreting Cells/ph [Physiology]
  • Interleukin-6/bl [Blood]
  • Islet Amyloid Polypeptide/bl [Blood]
  • Male
  • Middle Aged
  • Models
  • Oxygen/bl [Blood]
  • Retrospective Studies
  • S
  • Time Factors
  • Young Adult

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Authors

  • K Spliethoff

  • D Meier

  • I Aeberli

  • M Gassmann

  • W Langhans

  • M Maggiorini

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