Reduction of a wide range of tertiary amides with 2 molar equivalents of diphenylsilane was promoted by 0.1 mol% of RhH(CO)(PPh3)3 at room temperature, affording the corresponding tertiary amines in high yields. The synthetic utility is demonstrated by chemoselective reductions of amides having functional groups such as ester and epoxy groups which are not tolerated by the conventional reductions with LiAlH4 and BH3.
CITATION STYLE
Kuwano, R., Takahashi, M., & Ito, Y. (1998). Reduction of antides to amines via catalytic hydrosilylation by a rhodium complex. Tetrahedron Letters, 39(9), 1017–1020. https://doi.org/10.1016/S0040-4039(97)10804-8
Mendeley helps you to discover research relevant for your work.