Regional cerebral cortical thinning in bipolar disorder

  • Lyoo I
  • Sung Y
  • Dager S
 et al. 
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OBJECTIVE: This study was conducted to explore differences in
cortical thickness between subjects with bipolar disorder and
healthy comparison subjects using cortical surface-based
analysis. METHODS: Brain magnetic resonance images were
acquired from 25 subjects with bipolar disorder and 21 healthy
comparison subjects. Cortical surface-based analysis was
conducted using the Freesurfer application. Group differences
in cortical thickness, defined by the distance from gray/white
boundary to the pial surface, were assessed using statistical
difference maps. RESULTS: Subjects with bipolar disorder
exhibited significantly decreased cortical thickness in left
cingulate cortex, left middle frontal cortex, left middle
occipital cortex, right medial frontal cortex, right angular
cortex, right fusiform cortex and bilateral postcentral
cortices, relative to healthy comparison subjects (all p <
0.001). Duration of illness in bipolar subjects was inversely
correlated with the cortical thickness of the left middle
frontal cortex. CONCLUSIONS: Cortical thinning was present in
multiple prefrontal cortices in bipolar disorder. There was
also cortical thinning in sensory and sensory association
cortices, which has not been reported in previous studies
using region-of-interest or voxel-based morphometry methods.
Cortical thinning observed in the current study may be related
to impairment of emotional, cognitive, and sensory processing
in bipolar disorder but longitudinal studies will be necessary
to test this hypothesis.

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  • In Kyoon Lyoo

  • Young Hoon Sung

  • Stephen R Dager

  • Seth D Friedman

  • Jun-Young Lee

  • Seog Ju Kim

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