Regional homogeneity changes in patients with Parkinson's disease.

  • Wu T
  • Long X
  • Zang Y
 et al. 
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Abstract

Resting state brain activity in Parkinson's disease (PD) can give
clues to the pathophysiology of the disorder, and might be helpful
in diagnosis, but it has never been explored using functional MRI
(fMRI). In the current study, we used a regional homogeneity (ReHo)
method to investigate PD-related modulations of neural activity in
the resting state. FMRIs were acquired in 22 patients with PD at
both before and after levodopa administration, as well as in 22 age-
and sex-matched normal controls. In the PD group compared with the
healthy controls, we found ReHo decreased in extensive brain regions,
including the putamen, thalamus, and supplementary motor area; and
increased in some other areas, including the cerebellum, primary
sensorimotor cortex, and premotor area. The ReHo off medication was
negatively correlated with the Unified Parkinson's Disease Rating
Scale (UPDRS) in the putamen and some other regions, and was positively
correlated with the UPDRS in the cerebellum. Administration of levodopa
relatively normalized ReHo. Our findings demonstrate that neural
activity in the resting state is changed in patients with PD. This
change is secondary to dopamine deficiency, and related to the severity
of the disease. The different neuronal activity at the baseline state
should be considered in explaining fMRI findings obtained during
tasks.

Author-supplied keywords

  • Aged; Antiparkinson Agents
  • Computer-Assisted
  • blood supply/drug effects/pathology; Case-Control
  • blood; Parkinson Disease
  • drug therapy/pathology/physiopathology; Rest
  • methods; Levodopa
  • methods; Male; Middle Aged; Oxygen
  • pharmacology/therapeutic use; Brain Mapping; Brai
  • pharmacology/therapeutic use; Magnetic Resonance
  • physiology; Statistics as Topic

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Authors

  • Tao Wu

  • Xiangyu Long

  • Yufeng Zang

  • Liang Wang

  • Mark Hallett

  • Kuncheng Li

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