Regioselective reductive hydration of alkynes to form branched or linear alcohols

  • Li L
  • Herzon S
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Abstract

The regioselective reductive hydration of terminal alkynes using two complementary dual catalytic systems is described. Branched or linear alcohols are obtained in 75-96% yield with ≥25:1 regioselectivity from the same starting materials. The method is compatible with terminal, di-, and trisubstituted alkenes. This reductive hydration constitutes a strategic surrogate to alkene oxyfunctionalization and may be of utility in multistep settings.

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Authors

  • Le Li

  • Seth B. Herzon

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