Regulatory T cells in human disease and their potential for therapeutic manipulation

  • Taams L
  • Palmer D
  • Akbar A
 et al. 
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Abstract

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory pathologies in vivo. At a recent meeting [Clinical Application of Regulatory T Cells, 7-8 April 2005, Horsham, UK, organized by the authors of this review, in collaboration with the British Society for Immunology and Novartis] evidence was discussed that certain human autoimmune, infectious and allergic diseases are associated with impaired regulatory T-cell function. In contrast, evidence from several human cancer studies and some infections indicates that regulatory T cells may impair the development of protective immunity. Importantly, certain therapies, both those that act non-specifically to reduce inflammation and antigen-specific immunotherapies, may induce or enhance regulatory T-cell function. The purpose of this review was to summarize current knowledge on regulatory T-cell function in human disease, and to assess critically how this can be tailored to suit the therapeutic manipulation of immunity

Author-supplied keywords

  • Autoimmunity
  • Humans
  • Immune System Diseases
  • Immune Tolerance
  • Immunity
  • Immunotherapy
  • Infection
  • Inflammation
  • Neoplasms
  • T-Lymphocytes,Regulatory
  • immunology
  • methods
  • pathology
  • therapy

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  • PMID: 16630018

Authors

  • L S Taams

  • D B Palmer

  • A N Akbar

  • D S Robinson

  • Z Brown

  • C M Hawrylowicz

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