Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis

  • Zhang W
  • Likhodii S
  • Aref-Eshghi E
 et al. 
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OBJECTIVE: To investigate the relationship between plasma and synovial fluid (SF) metabolite concentrations in patients with osteoarthritis (OA). METHODS: Blood plasma and SF samples were collected from patients with primary knee OA undergoing total knee arthroplasty. Metabolic profiling was performed by electrospray ionization tandem mass spectrometry using the AbsoluteIDQ kit. The profiling yielded 168 metabolite concentrations. Correlation analysis between SF and plasma metabolite concentrations was done on absolute concentrations as well as metabolite concentration ratios using Spearman's rank correlation (rho) method. RESULTS: A total of 69 patients with knee OA were included, 30 men and 39 women, with an average age of 66 +/- 8 years. For the absolute metabolite concentrations, the average rho was 0.23 +/- 0.13. Only 8 out of 168 metabolite concentrations had a rho >/= 0.45, with a p value /= 0.52 and a p value

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  • W. Zhang

  • Sergei Likhodii

  • Erfan Aref-Eshghi

  • Yuhua Zhang

  • Patricia E. Harper

  • Edward Randell

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