The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort

  • L.K.M. B
  • P.K. M
  • A. J
 et al. 
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Background Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary magnesium intake was associated with BP, total cholesterol (TC) and incident stroke risk in an adult population. Methods We conducted cross-sectional analyses in a case-cohort study of 4443, men and women aged 40-75, representative of 25,639 participants years of the EPIC (European Prospective Investigation into Cancer)-Norfolk cohort. The cohort included 928 stroke cases (42,556.5 person years). Dietary data from 7 day food diaries were analysed using multivariate regression to assess associations between quintiles or data-derived categories of dietary magnesium intake and BP, TC and stroke risk, adjusted for relevant confounders. Results We observed differences of - 7 mm Hg systolic BP (P trend ≤ 0.01) and - 3.8 mm Hg diastolic BP (P trend = 0.01) between extreme intakes of magnesium in men, a significant inverse association with TC was observed (P trend = 0.02 men and 0.04 women). Compared to the bottom 10%, the top 30% of magnesium intake was associated with a 41% relative reduction in stroke risk (HR 0.59; 95% CI 0.38-0.93) in men. Conclusions Lower dietary magnesium intake was associated with higher BP and stroke risk, which may have implications for primary prevention.

Author-supplied keywords

  • adult
  • aged
  • article
  • blood pressure
  • body mass
  • cerebrovascular accident
  • cholesterol
  • cholesterol blood level
  • cohort analysis
  • cross-sectional study
  • diastolic blood pressure
  • disease association
  • drug use
  • educational status
  • female
  • follow up
  • gender
  • human
  • hypertension
  • magnesium intake
  • major clinical study
  • male
  • patient risk
  • physical activity
  • primary prevention
  • priority journal
  • risk factor
  • risk reduction
  • sensitivity analysis
  • smoking
  • systolic blood pressure

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  • Bain L.K.M.

  • Myint P.K.

  • Jennings A.

  • Lentjes M.A.H.

  • Luben R.N.

  • Khaw K.-T.

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