Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese

  • Suzuki K
  • Ito Y
  • Ochiai J
 et al. 
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The present study was conducted to assess the relationship between obesity and serum levels of C-reactive protein (CRP), carotenoids, oxidized LDL (oxLDL), oxidized LDL antibodies (oLAB), and leptin in Japanese residents. The subjects were 158 males and 158 females aged 40-79 years, and living in Hokkaido, Japan, who attended a health examination screening. Serum levels of CRP, oxLDL, oLAB, and leptin were measured by enzyme-linked immunosorbent assay (ELISA) and serum carotenoid levels were measured by high-performance liquid chromatography (HPLC). Body mass index (BMI) was calculated as body weight (kg) divided by height (m) squared and obesity was defined as BMI of 25 or more (kg/m2). Serum levels of CRP and leptin were significantly higher in the obese group than in their non-obese counterparts in both genders. Serum levels of beta-carotene and beta-cryptoxanthin were lower in the obese individuals, especially in females. While values for oxLDL and oLAB did not significantly vary. BMI was positively correlated with log-transformed serum levels of CRP and leptin in both genders (males: r=0.231, p

Author-supplied keywords

  • *Oxidative Stress
  • Adult
  • Aged
  • Autoantibodies/blood/immunology
  • Biomarkers/*blood
  • C-Reactive Protein
  • Cholesterol, LDL/blood/immunology
  • Cryptoxanthins
  • Female
  • Humans
  • Inflammation/*complications
  • Japan
  • Leptin/blood
  • Male
  • Middle Aged
  • Obesity/*blood/complications/pathology
  • Peptide Fragments/blood
  • Xanthophylls
  • beta Carotene/*analogs & derivatives/blood

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  • K Suzuki

  • Y Ito

  • J Ochiai

  • Y Kusuhara

  • S Hashimoto

  • S Tokudome

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