Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma.

  • Alexandrakis M
  • Sfiridaki A
  • Miyakis S
 et al. 
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BACKGROUND: Multiple myeloma is characterized by accumulation of plasma cells in the bone marrow, with osteolysis and increased marrow angiogenesis. We studied molecules involved in angiogenesis (MMP-9, HGF, VEGF) in relation to disease stage, extent of bone destruction, and markers of bone turnover (Ntx and PICP).

METHODS: MMP-9, HGF, VEGF were measured in the serum of 42 newly diagnosed myeloma patients and 24 controls with commercial ELISA kits. Urinary levels of Ntx were measured by ELISA, and serum PICP with RIA. Extent of radiological bone disease was graded into low and high score. Stage was estimated according to the Durie-Salmon criteria.

RESULTS: HGF, VEGF and Ntx were higher in patients than controls (p
CONCLUSIONS: Angiogenesis and bone destruction are closely interrelated in myeloma, and cytokine levels (MMP-9, VEGF and HGF) may be useful in monitoring progression.

Author-supplied keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Markers
  • Biological Markers: blood
  • Bone Diseases
  • Bone Diseases: diagnosis
  • Bone Diseases: etiology
  • Collagen Type I
  • Collagen Type I: blood
  • Female
  • Hepatocyte Growth Factor
  • Hepatocyte Growth Factor: blood
  • Humans
  • Male
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 9: blood
  • Middle Aged
  • Multiple Myeloma
  • Multiple Myeloma: complications
  • Neovascularization, Pathologic
  • Neovascularization, Pathologic: diagnosis
  • Neovascularization, Pathologic: etiology
  • Peptide Fragments
  • Peptide Fragments: blood
  • Peptides
  • Peptides: blood
  • Procollagen
  • Procollagen: blood
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factor A: blood

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  • Michael G Alexandrakis

  • Aikaterini Sfiridaki

  • Spiros Miyakis

  • Constantina Pappa

  • Ermioni Kandidaki

  • Athanassios Alegakis

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