The Relationship of Nocturnal Melatonin to Estradiol and Progesterone in Depressed and Healthy Pregnant Women

  • Posadas E
  • Meliska C
  • Martinez L
 et al. 
  • 26


    Mendeley users who have this article in their library.
  • 5


    Citations of this article.


PURPOSE: To assess the relationship between nocturnal plasma melatonin and serum estradiol (E(2)) and progesterone (P(4)) levels in depressed pregnant women (DW) and matched healthy women (HW).

METHODS: We used analysis of variance (ANOVA) and linear regression analyses on data obtained from pregnant HW and DW.

RESULTS: Log E(2) and log P(4) were positively correlated with measures of melatonin quantity in HW (p
CONCLUSIONS: Pregnant DW may be less sensitive than HW to modulation of melatonin secretion by E(2) and P(4). That melatonin timing measures are more sensitive to E(2) and P(4) variation in DW may reflect a circadian system more attuned to the need for realignment in DW than in HW. These altered sensitivities to reproductive hormones may reflect a biologic vulnerability that predisposes some pregnant women to depression.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Emerson S. Posadas

  • Charles J. Meliska

  • Luis F. Martinez

  • Diane L. Sorenson

  • Ana M. Lopez

  • Sara Nowakowski

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free