Relevance of biologic markers in colorectal carcinoma: A comparative study of a broad panel

  • Barozzi C
  • Ravaioli M
  • D'Errico A
 et al. 
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Abstract

Although pathologic stage is currently the main prognostic indicator for patients with colorectal carcinoma (CRC), mounting evidence suggests that, in its current form, it is insufficient to predict clinical outcome. To assess biologic markers of primary CRC that may improve clinical staging and provide useful information for the application of novel therapeutic strategies, the authors investigated a panel of markers that included transforming growth factor- (TGF-), epithelial growth factor receptor (EGF-R; the protein product of the c-erb B2/HER-2 oncogene), matrix metalloproteinase 2 (MMP-2), insulin-like growth factor II (IGFII), vascular endothelial growth factor (VEGF), and angiogenesis, as evaluated by microvessel density (MVD).

Author-supplied keywords

  • Biologic markers
  • Colorectal carcinoma
  • Insulin-like growth factor II
  • Liver metastasis
  • Logistic regression
  • Matrix metalloproteinase 2
  • Transforming growth factor-??

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