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Journal article

Relevance of macro creatine kinase type 1 and type 2 isoenzymes to laboratory and clinical data

Lee K, Csako G, Bernhardt P, Elin R ...see all

Clin.Chem., vol. 40, issue 0009-9147 (Print) (1994) pp. 1278-1283

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From 8322 patients for whom creatine kinase (CK; EC isoenzyme analysis was ordered, we identified 136 patients with macro CK isoenzyme in their serum. There were 36 cases with type 1 (prevalence: 0.43%) and 100 cases with type 2 isoenzyme (prevalence: 1.20%). About three-fourths of the patients were ambulatory at the time of testing, and approximately 90% of the first 68 patients identified survived at least 1 year after macro CK was found in their serum. Age and gender did not differ significantly between the two groups. The serum total CK was significantly higher (P < 0.0005), and an increased CK-MB proportion (> 0.05 of total CK) was also significantly more common (P < 0.0005) in patients with macro CK type 1 than in those with type 2. On average, macro CK type 2 accounted for approximately 25% and macro CK type 1 for approximately 10% of the serum total CK activity. Patients with macro CK type 1 most often had myositis, whereas those with macro CK type 2 most commonly had a malignancy. We conclude that the presence of macro CK isoenzymes has a low prognostic value for impending death, but may support the diagnosis of an autoimmune process (type 1) or malignant cell proliferation (type 2)

Author-supplied keywords

  • Adenylate Kinase
  • Adolescent
  • Adult
  • Aged
  • Antibodies
  • Cell Proliferation
  • Creatine
  • Creatine Kinase
  • Death
  • False Positive Reactions
  • Female
  • Humans
  • Isoenzymes
  • Laboratories
  • Macromolecular Substances
  • Male
  • Middle Aged
  • Molecular Weight
  • Myositis
  • Neoplasms
  • Patients
  • Prevalence
  • Reference Values
  • Serum
  • analysis
  • antagonists & inhibitors
  • blood
  • chemistry
  • diagnosis
  • enzymology
  • pathology
  • pharmacology

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  • PMID: 8013099


  • K N Lee

  • G Csako

  • P Bernhardt

  • R J Elin

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