Remodeling the plasticity debate: The presynaptic locus revisited

Abstract

The cellular mechanisms contributing to long-term potentiation and activity-induced formation of glutamatergic synapses have been intensely debated. Recent studies have sparked renewed interest in the role of presynaptic components in these processes. Based on the present evidence, it appears likely that long-term plasticity utilizes both pre- and postsynaptic expression mechanisms. ©2006 Int. Union Physiol. Sci./Am. Physiol. Soc.